This program will utilise the multiscale computational models and simulation outputs and detailed characterisation and mapping of shoulder joint biomechanics to inform the design, development, optimisation and validation of engineered scaffolds for rotator cuff repair. The integration of underlying biochemical and biomechanical cues associated with de novo tissue generation within the shoulder joint into bespoke designed, biomechanically-matched, engineered scaffolds will significantly improve upon the current empirical process applied to developing tissue scaffolds for interfacial musculoskeletal tissues (such as the rotator cuff). Thiswill further inform how tissue generation in these scaffolds can be enhanced through fit-for-purpose rehabilitation post-surgery to encourage functional tissue repair and improve patient outcomes.